The information on this page is educational. It describes how Reforge Health thinks about metabolic health. It is not medical advice, diagnosis, or a treatment recommendation. Consult a qualified healthcare provider before making changes to your health regimen.
Low mood and depression
Low mood and depression. The metabolic connection your psychiatrist may not have mentioned.
Depression is treated as a neurotransmitter problem. The serotonin model has dominated for decades, and SSRIs remain the first-line intervention in most clinics. The metabolic spectrum reads a different picture.
Chronic inflammation is now one of the most studied contributors to depressive symptoms. Insulin resistance impairs cerebral glucose metabolism. Gut dysbiosis alters tryptophan metabolism, the precursor pathway to serotonin. Vitamin D deficiency, omega-3 insufficiency, and magnesium depletion each have documented associations with mood disruption.
We do not dismiss pharmaceutical intervention where it is needed. We read the metabolic environment alongside the mood picture and build a framework that addresses both.
The spectrum does not wait for a diagnosis.
If you recognise yourself in any of these conditions, or in the spaces between them, the Metabolic Questionnaire is a good starting point. It is not a diagnosis. It is a structured way to map your symptoms and history so that the right conversation can follow.
